Conditions we treat
None of these is a diagnosis we make. They are the patterns clients arrive with, and each one has recognisable genetic and nutrient roots we can read, test and support alongside your doctor.
Tired on waking, worse by mid-afternoon, and blood work that comes back "normal". Persistent fatigue is usually an energy-production problem: mitochondria short on cofactors, a methylation cycle that can't keep up with demand, or both. Stress, poor sleep and hidden infections raise the cost; genetics sets how much margin you had to begin with.
Losing words, rereading the same paragraph, forgetting why you walked into a room. The brain is the most energy-hungry organ and the most sensitive to methylation, inflammation and blood-sugar swings. Slow COMT or MTHFR variants, low B12 or choline, and histamine load are frequent contributors.
Feeling wired and flat at the same time. Neurotransmitter production and clearance are governed by a handful of genes, and methylation supplies the raw materials. A slow COMT keeps adrenaline and dopamine circulating; a slow MTHFR starves serotonin synthesis. The right support depends on which pattern you carry.
Trouble switching off, waking at 3am, or sleeping eight hours and still feeling flat. Circadian genes decide whether you're built for early or late; caffeine-metabolism genes decide whether your 2pm coffee is still active at midnight. Low magnesium and an over-active stress response do the rest.
Heavy or painful cycles, mood swings that track the calendar, hot flushes years earlier than expected. Oestrogen has to be broken down and cleared, and both steps run through methylation and detox genes. When clearance lags, symptoms of "oestrogen dominance" appear even with normal hormone levels.
Food reactions that shift week to week, bloating after almost anything, bowel habits that never settle. Genetics shapes lactose tolerance, gluten sensitivity, gut-lining integrity and the microbiome you tend to grow. A stressed nervous system slows digestion further.
Stiffness in the morning, aches that move around, slow recovery from exercise, a CRP that sits just above range. Inflammation genes set your baseline "volume", and nutrient status decides how quickly it turns back down. Omega-3 conversion genes matter more than most people realise.
Migraine has one of the clearest links to MTHFR and homocysteine of any common complaint, and it responds to a fairly predictable set of nutrients. Histamine load, oestrogen swings and mitochondrial energy supply all feed into the same trigger threshold.
Difficulty conceiving, recurrent early loss, or simply wanting to prepare well. Folate metabolism is central to egg quality, implantation and early development, and MTHFR variants change which form of folate the body can actually use. Partners' genetics matter too.
Headaches from perfume or wine, symptoms that improve on holiday, reactions to foods that were fine last year. Detox genes decide how fast you activate and clear toxins; histamine genes decide how much load you tolerate. Mold exposure hits people with slower clearance first and hardest.
These summaries are educational. Best U Genetics does not diagnose or treat medical conditions; we help you understand genetic tendencies and support them with food, lifestyle and nutrients alongside your doctor.
A free 20-minute discovery call. We'll hear what's going on, tell you honestly whether genetic testing is likely to help, and outline what working together would look like.