Tests & pricing

One DNA kit. A complete genetic picture.

A single cheek swab is analysed on a validated precision-health platform, then read by a practitioner who connects it to your symptoms, your labs and your goals.

We never share your dataHIPAA & GDPR policiesWorld-class encryption

See pricing The ten focus reports

1,500+genetic health reports

200Mvariants in the SNP database

4,000+lab markers with functional ranges

30 SNPsin the methylation pathway report

The pathway reports we read in depth

Most DNA tests hand you a list of variants. A pathway report places each variant on the map of the biology it belongs to, alongside your lab results, so the bottlenecks and the fixes are visible on one page. These four are the core of our work because they explain the conditions people bring to us most.

Pathway report · 30 SNPs across 24 genes

Methylation Pathway

Methylation is the transfer of a methyl group from one compound to another. Those methyl groups act as switches that turn genes on and off, signal which hormones, brain chemicals and amino acids need to be broken down, and keep homocysteine in check. The cycle starts with folate from food and the MTHFR enzyme, runs through vitamin B12 and the MTR/MTRR enzymes to produce SAM-e, the body's universal methyl donor, and exits through the B6-dependent transsulfuration pathway that makes glutathione.

Genes analysed

MTHFR (C677T, A1298C), MTR, MTRR, MTHFD1, MTHFD1L, MTHFS, SHMT1, DHFR, FOLH1, TYMS, TCN2, CUBN, FUT2, MAT1A, GNMT, AHCY, BHMT, CHDH, PEMT, COMT, DNMT3B, CBS, PDXK

Lab markers the report asks for

Homocysteine, folate and RBC folate, B12 and active B12, methylmalonic acid, riboflavin, B6, choline, betaine, SAM-e/SAH, glycine, serine, magnesium, zinc, total glutathione

Typical recommendations

Methylfolate in place of folic acid · methyl- or hydroxo-B12 · riboflavin (B2) as the MTHFR cofactor · betaine (TMG) · choline-rich foods · B6 (P5P) · magnesium and zinc · limiting alcohol

Why we use it

This is the report our practice is built around. A single MTHFR result means little on its own; the value is in seeing the whole cycle, where the bottlenecks are and which cofactors will relieve them.

Helps explain:

Chronic fatigue Brain fog Anxiety & mood Migraines Fertility Hormones & PMS

Pathway report · 27 SNPs across 16 genes

Histamine Pathway

Histamine protects you from invaders, keeps you awake and drives stomach acid. It enters the body from food (aged cheese, wine, fermented foods, some fish), from mast cells and from gut bacteria, and is cleared by two enzymes: DAO in the gut and HNMT inside cells and the brain. When supply outruns clearance, symptoms look like an allergy without an allergen: headaches, flushing, hives, bloating, a runny nose, racing thoughts at night.

Genes analysed

AOC1 (DAO), HNMT, HDC, MAOA, MAOB, NAT2, ALDH2, FCER1A, HRH1, HRH2, HRH4, IL4, IL13, TNF, ESR1, GPX1, MTHFR

Lab markers the report asks for

Plasma histamine, IgE, basophils and eosinophils, CRP and hs-CRP, homocysteine, riboflavin, selenium, glutathione peroxidase, estradiol, TNF-alpha

Typical recommendations

Vitamin C to support DAO · quercetin to calm mast cells · riboflavin · betaine (TMG) to fuel HNMT via SAM-e · B6 · a low-histamine phase during flares · limiting alcohol, which blocks DAO

Why we use it

Histamine sits at the crossroads of methylation, hormones and the gut. Slow HNMT plus a slow MTHFR is a very different picture from low DAO alone, and the support is different too.

Helps explain:

Chemical, mold & histamine sensitivity Migraines Digestive Sleep Inflammation Anxiety & mood

Pathway report · 35 SNPs across 24 genes

Detox Pathway

Detoxification is the body's cleaning service, mostly run by the liver in two phases. Phase I enzymes (the CYP family) start breaking toxins down, sometimes making them more reactive in the process. Phase II enzymes then neutralise those intermediates by attaching glutathione, sulfate, glucuronic acid or an acetyl or methyl group so they can leave in bile and urine. The report maps both phases against real exposures: mold, pesticides, plastics, smoke, alcohol, medications and your own hormones.

Genes analysed

Phase I: CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP3A4, AHR, ADH1B, ALDH2, PON1. Phase II: GSTP1, GSTA1, GCLC, NQO1, NFE2L2 (NRF2), SULT1A1, UGT1A1, NAT1, NAT2, COMT, SLCO1B1

Lab markers the report asks for

ALT, AST, GGT, bilirubin, total glutathione, cysteine, selenium, vitamin C, magnesium, heavy metals (mercury, lead, arsenic, cadmium), 8-OHdG for oxidative DNA damage, estrogen metabolites (DUTCH)

Typical recommendations

Reduce exposure first · NAC or glutathione · sulforaphane from cruciferous vegetables · selenium · milk thistle · binders under supervision where mold or metals are involved · magnesium, zinc and vitamin C as cofactors

Why we use it

Two people can live in the same water-damaged building and only one gets sick. Variants in GSTA1, SLCO1B1 and NRF2 are a large part of why, and they tell us which support to reach for first.

Helps explain:

Chemical, mold & histamine sensitivity Hormones & PMS Inflammation Chronic fatigue Brain fog Migraines

Pathway report · neurotransmitter synthesis and clearance

Dopamine Pathway

Dopamine drives motivation, focus, reward and the sense that effort is worth it. It is built from tyrosine in two steps that need iron, BH4 and vitamin B6, converted onward to noradrenaline and adrenaline, and cleared by COMT and the MAO enzymes. Genetics decides how fast each step runs. The well-known COMT "worrier/warrior" variant is one piece; receptor and transporter genes decide how strongly the signal lands.

Genes analysed

TH, DDC, DBH, COMT, MAOA, MAOB, DRD2, DRD4, SLC6A3 (DAT), plus the methylation genes that supply SAM-e for COMT

Lab markers the report asks for

Urinary or organic-acid dopamine metabolites (HVA, VMA), ferritin and iron, copper, B6, riboflavin, magnesium, homocysteine

Typical recommendations

Magnesium and SAM-e support for slow COMT · riboflavin for MAO · iron and B6 only where tested low · tyrosine-rich protein at breakfast · caffeine and stimulant limits set by your metaboliser status · sleep and light exposure to reset the system

Why we use it

Anxiety that ramps up under pressure, low motivation, ADHD-type focus problems and poor tolerance of caffeine often trace back to the same handful of genes. This report separates a supply problem from a clearance problem.

Helps explain:

Anxiety & mood Brain fog Chronic fatigue Sleep

What every report contains

The same six-part structure in each pathway report, so results are easy to follow and easy to compare over time.

How this works

A plain-language explanation of the pathway before any results.

Pathway map

Your genotypes and lab values placed on the diagram, colour-coded from optimal to significantly out of range.

Results overview

Overall predisposition and a summary of every gene-SNP pair with your genotype.

Gene-by-gene breakdown

What each enzyme does, the blockers that slow it, the enhancers that support it, and the research behind each variant.

Prioritised recommendations

Ranked by likely impact and strength of evidence, each one tied to the specific variants it addresses, with typical starting doses.

Lab markers to check

Which blood and urine tests confirm whether a tendency is actually showing up, tracked over time on functional ranges.

Supporting reports

Used alongside the pathway reports to turn findings into a daily plan.

Health Overview

The one-page starting point: your highest-priority genetic risks across all systems, ranked, with the top recommendations pulled through. It is the document we open first in every results session and the one you can hand to your doctor.

Health overview

4priority areas

Methylation

Histamine

Detox

Inflammation

Diet & Nutrition

Macronutrient ratios, vitamin and mineral needs, and food-sensitivity tendencies (lactose, gluten, caffeine, histamine) based on your genes, with recipes and shopping lists. Where the pathway reports say what is slow, this says what to eat.

Diet & nutrition

12nutrient targets

Folate need

Choline need

Omega-3 conv.

Vitamin D

Fitness

Recovery speed, injury tendency, endurance vs power leaning, and how exercise affects your inflammation and energy genes. Used to set a movement plan that builds mitochondria without triggering a crash.

Fitness

Zone 2starting point

Recovery

Endurance

Injury risk

VO2 response

Which report explains which condition

Reports overlap on purpose. A dot means we read that report closely for that condition.

Report	Chronic fatigue	Brain fog	Anxiety & mood	Sleep	Hormones & PMS	Digestive	Inflammation	Migraines	Fertility	Chemical, mold & histamine sensitivity
Methylation Pathway
Histamine Pathway
Detox Pathway
Dopamine Pathway
Health Overview
Diet & Nutrition
Fitness

Ten focus areas from the wider library

Beyond the pathway reports, these are the ten areas we check for every client. Open any of them to see what it measures, the symptoms it can help explain, and the support we commonly discuss.

Methylation pathway

The core report. Folate and B-vitamin metabolism, homocysteine recycling, methyl-group supply.

What it shows

How efficiently you convert folate and B12 into their active forms and how well you recycle homocysteine. This is the engine behind DNA repair, neurotransmitter production and detoxification.

Genes include MTHFR, MTR, MTRR, COMT, CBS, PEMT, SHMT1, BHMT.

Symptoms it may explain

Persistent fatigue, brain fog, low mood or anxiety, elevated homocysteine on blood work, poor response to standard folic acid, recurrent pregnancy loss history, migraines.

Support we may discuss

Methylfolate (5-MTHF) in place of folic acid, methyl- or hydroxo-B12, riboflavin (B2) as the MTHFR cofactor, B6, trimethylglycine (TMG), choline-rich foods.

Detox pathway

Phase I and Phase II liver detoxification and antioxidant defence.

What it shows

How quickly you activate toxins (Phase I) versus how well you neutralise and clear them (Phase II), plus your capacity to mop up the oxidative stress produced along the way.

Genes include CYP1A2, CYP2D6, GSTM1, GSTP1, NAT2, SOD2, NQO1.

Symptoms it may explain

Headaches from wine, perfume or cleaning products; feeling wired after one coffee; chemical sensitivity; sluggish recovery after alcohol or medications; frequent sinus or skin flare-ups.

Support we may discuss

N-acetylcysteine (NAC) or liposomal glutathione, sulforaphane from broccoli sprouts, milk thistle, cruciferous vegetables, reducing exposure load before adding supplements.

Gut health

Digestive enzymes, microbiome tendencies, food-related immune triggers.

What it shows

Genetic tendencies toward lactose and gluten sensitivity, how your gut lining and microbiome are likely to behave, and whether you carry the immune markers associated with coeliac-type reactions.

Genes include FUT2, MCM6 (lactase), HLA-DQ2/DQ8, IL-10, NOD2.

Symptoms it may explain

Bloating, irregular bowel habits, reflux, food reactions that shift week to week, low B12 despite a good diet, skin issues that track with what you eat.

Support we may discuss

Targeted probiotics and prebiotic fibres, digestive enzymes with meals, L-glutamine or zinc carnosine for the gut lining, a structured elimination trial where appropriate.

Inflammation

Your baseline inflammatory "volume knob" and how fast it turns down.

What it shows

Variants that tune the production and clearance of inflammatory messengers, and how strongly your body responds to everyday triggers like poor sleep, processed fats or infection.

Genes include IL-6, TNF, CRP, IL-1B, IL-10.

Symptoms it may explain

Joint stiffness, slow recovery after exercise, puffiness, mildly elevated CRP, eczema or asthma flares, aches that move around.

Support we may discuss

Omega-3 fish oil (EPA/DHA), curcumin with piperine, quercetin, a Mediterranean-style pattern of eating, vitamin D if levels are low.

Mood & stress resilience

Neurotransmitter production and breakdown, stress hormone sensitivity.

What it shows

How quickly you clear dopamine, adrenaline and serotonin, how your brain supports new connections, and how reactive your stress response tends to be.

Genes include COMT, MAOA, BDNF, SLC6A4, TPH2, FKBP5.

Symptoms it may explain

Anxiety that ramps up under pressure, irritability, low motivation, feeling flat, poor tolerance to caffeine or stimulants, sleep that suffers with stress.

Support we may discuss

Magnesium glycinate, L-theanine, B6 (P5P), adaptogens such as rhodiola or ashwagandha, careful pacing of methyl donors in "slow COMT" profiles.

Sleep

Circadian rhythm, melatonin production, caffeine sensitivity.

What it shows

Whether you lean early-bird or night-owl, how your body makes and clears melatonin, and how long caffeine stays active in your system.

Genes include CLOCK, PER2, ADORA2A, CYP1A2, MTNR1B.

Symptoms it may explain

Trouble falling or staying asleep, waking unrefreshed, afternoon crashes, sensitivity to late-day coffee, difficulty adjusting to schedule changes.

Support we may discuss

Magnesium, glycine before bed, timed light exposure, caffeine cut-off tailored to your metaboliser status, low-dose melatonin only when the pattern warrants it.

Energy & mitochondria

Cellular energy production and antioxidant recycling.

What it shows

How efficiently your mitochondria turn fuel into ATP, how well you make and recycle CoQ10 and carnitine, and how much oxidative stress your cells generate doing it.

Genes include PPARGC1A, NDUFS, COQ2, SLC22A5, SOD2, UCP2.

Symptoms it may explain

Fatigue that doesn't match your sleep, exercise intolerance, muscle soreness that lingers, post-viral tiredness, "hitting a wall" mid-afternoon.

Support we may discuss

Coenzyme Q10 (ubiquinol), acetyl-L-carnitine, B-complex, magnesium, creatine, graded movement rather than push-and-crash.

Hormone balance

Oestrogen metabolism and clearance, testosterone and thyroid tendencies.

What it shows

Which routes your body uses to break down oestrogen, how quickly those metabolites are cleared (this overlaps with methylation), and genetic tendencies in androgen and thyroid signalling.

Genes include CYP1B1, CYP19A1, COMT, SULT1A1, SHBG, DIO2.

Symptoms it may explain

Heavy or painful cycles, PMS, perimenopausal symptoms out of proportion to age, oestrogen-dominant patterns, low libido, stubborn weight around the middle.

Support we may discuss

Cruciferous vegetables and DIM or indole-3-carbinol, calcium-D-glucarate, magnesium, adequate fibre for clearance, methylation support where COMT is slow.

Vitamin & nutrient needs

Which nutrients you absorb, convert and use less efficiently.

What it shows

Whether you convert beta-carotene to vitamin A well, how your vitamin D receptor behaves, how efficiently you make omega-3s from plant sources, and your choline and B12 handling.

Genes include VDR, BCMO1, FADS1/FADS2, PEMT, FUT2, TCN2.

Symptoms it may explain

Low vitamin D despite sun and supplements, dry eyes and skin on a plant-based diet, fatty liver tendencies, deficiencies that keep coming back on labs.

Support we may discuss

Vitamin D3 with K2, preformed vitamin A, EPA/DHA rather than flax alone, choline or phosphatidylcholine, dosing guided by follow-up blood work.

Heart & metabolic health

Cholesterol handling, blood sugar regulation and cardiovascular tendencies.

What it shows

Genetic tendencies in how you process fats and carbohydrates, your lipoprotein profile, and whether elevated homocysteine is likely to be part of your cardiovascular picture.

Genes include APOE, LPA, TCF7L2, PPARG, MTHFR, ACE.

Symptoms it may explain

Cholesterol that stays high on a "clean" diet, blood sugar swings and cravings, energy dips after carbohydrate-heavy meals, family history of early heart disease.

Support we may discuss

Omega-3s, soluble fibre, B-vitamin support for homocysteine, magnesium, chromium or berberine only in coordination with your prescribing doctor, movement after meals.

Reports describe genetic tendencies, not diagnoses. Supplement suggestions are starting points for a conversation, not a prescription; doses, forms and timing are set individually and reviewed against your blood work and any medications you take.

Also on the platform

1,500+ reports

Ancestry-adjusted polygenic risk across conditions and traits, drawn on when your history points beyond the core pathways.

Longevity screener

Ten-year and lifetime risk for 30+ chronic conditions, reviewed with your physician for prevention planning.

Pharmacogenomics

How your genes affect 50+ common medications, based on CPIC, FDA and DPWG guidelines. Information for your prescriber, not advice from us.

Carrier status

Screening for 40+ inherited conditions, explained plainly and referred on to a genetic counsellor where appropriate.

How this compares with a typical consumer DNA kit

	Best U Genetics	Typical consumer kit
Health reports	1,500+	Under 50
SNPs analysed	200 million	Under 70,000
Lab biomarkers analysed	4,000+	Under 48
Recommendations in database	20,000+	Under 50
Scientific references within reports	100,000+	Under 1,000
Ancestry-adjusted polygenic risk	Yes	Rarely
Algorithm validated on 2M+ public genomes	Yes	No
Raw DNA upload & download	Yes	Sometimes
HIPAA & GDPR compliant	Yes	Varies
Practitioner-led interpretation	Included	Not offered

Platform figures are published by the platform provider and describe the analysis engine; "typical consumer kit" figures are estimates from publicly available information. Practitioner-led interpretation, protocols and coaching are provided by Best U Genetics.

Pricing

Three ways to work with us. Every option includes the DNA kit (or analysis of raw data you already own) and full access to your reports.

Test + results session

Understand

[$ ___]

DNA collection kit and lab processing
All reports, including the ten focus reports
90-minute results session, recorded
Written summary of priority findings

Book a discovery call

Protocol

[$ ___]

Everything in Understand
Baseline lab review with functional ranges
Full written food, lifestyle and supplement protocol
One follow-up session at 8–12 weeks

Book a discovery call

Ongoing coaching

Transform

[$ ___ / month]

Everything in Protocol
Monthly coaching sessions
Protocol adjustments as retests come in
Message support between sessions

Book a discovery call

Already have raw data from 23andMe or AncestryDNA? Ask about the reduced rate for analysis without a new kit.

Testing questions

How is the sample collected?

A cheek swab or saliva sample, at home, with a prepaid return mailer. No needles, no clinic visit.

How long do results take?

Typically 3–5 weeks from the day the lab receives your sample. Raw-data uploads are usually processed within days.

Is the platform scientifically validated?

The analysis engine uses ancestry-adjusted polygenic risk models that have been benchmarked against public genome datasets and published in peer-reviewed journals. We are happy to share the papers.

Who sees my data?

You, your practitioner, and the platform's secure processing systems. We never sell or share your data, and you can download or delete it at any time.

Is this a medical test?

No. It is a wellness and education tool. Nothing in the reports is a diagnosis, and anything that warrants medical attention is referred to your physician.

Not sure which option fits?

A free 20-minute discovery call. We'll hear what's going on, tell you honestly whether genetic testing is likely to help, and recommend the right starting point.